 The
Neural and Vascular Biology (NVB) Theme at the Ordway Research Institute
encompasses research programs focused on neural and vascular diseases
including atherosclerosis, hypertension, and stroke.
Laboratories in the NVB are involved in identification
of methods and pharmaceuticals to prevent neurovascular injury and
to decrease morbidity and mortality due to neurovascular disease.
Various laboratories seek to understand mechanisms
leading to development of vascular disease as related to hyperlipidemia;
prevention of disease by reducing confounding risk factors; and
reduction in the severity of ischemic injury following heart failure
and stroke by understanding the mechanisms of tissue damage that
are initiated.
Research groups in NVB employ a large array of
technologies including:
- Electrophysiology
- Cell culture models
- Cell transport studies
- Confocal microscopy
- Gas chromatography-mass
spectrometry
- Immunocytochemistry,
protein purification (for three-dimensional studies)
- Complex lipid biochemistry
and analysis
- Whole animal studies
(for both stroke physiology and metabolic experiments)
Research efforts within NVB are supported
by common state-of-the-art instrumentation and by Core Facilities
at the Ordway Research Institute and the affiliated Wadsworth Center.
Principal Investigators for the Neural
and Vascular Biology Theme
Paul Black,
Ph.D.
M. Julia Brosnan, Ph.D.
Concetta DiRusso, Ph.D.
Harold K. Kimelberg, Ph.D.
Min Zhou, Ph.D.
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