SENIOR SCIENTIST
Ordway Research Institute

RESEARCH SCIENTIST
Stratton Veterans Administration Medical Center, Albany

CONTACT
Signal Transduction Laboratory
Phone: (518) 641-6428
Fax: (518) 641-6304
hlin@ordwayresearch.org

Hung-Yun Lin, Ph.D.

Research Focus

Dr. Lin and his Signal Transduction Laboratory team study molecular mechanisms of induction of apoptosis in cancer cells. Most of these mechanisms are p53-dependent and involve pharmacologic approaches to post-translational modifications of mutated, as well as wild-type, p53 or other transactivator proteins to promote programmed cell death. The post-translational modifications are dictated by signal transduction cascades. Human cancer cell models include prostate, breast, lung and head-and-neck tumors.

Other studies in the laboratory include membrane-initiated actions of non-peptide hormones, identification of membrane receptor proteins for non-peptide hormones and post-translational modifications of the superfamily of nuclear hormone receptors. The contribution of prostaglandins to tumorigenesis is also studied.

Selected Publications (View)

• Lin H.Y., Sun M.Z., Tang H.Y., Lin C, Incerpi S, Mousa S.A., Davis F.B., and Davis P.J.  (2009). Activation by thyroid hormone of mitogen-activated protein kinase and phosphatidylinostol 3-kinase: L-thyroxine vs 3,5,3’-triiodo-L-thyronine and cancer cell proliferation. Am J Physiol Cell Biology Accepted
• Lin H.Y., Sun M.Z., Lin C, Tang H.Y., London D., Shih A., Davis F.B., and Davis P.J.  (2009). Mechanisms of androgen-induced breast cancer. J Steriods Biochem Mol Biol. In press
• Davis P.J., Davis F.B., Lin H.Y. (2008). Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors.  Steroids 73:1013-1007
• Lin H.Y., Sun M.Z., Tang H.Y., Wu Y.-H., Grandis J.R., Cao H.J., Davis P.J., and Davis F.B. (2008). Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells.  J. Cell. Biochem. 104:2131-2142.
• Lin H.Y., Tang H.Y., Keating T., Wu Y.-H., Shih A., Hammond D., Sun M.Z., Hercbergs A., Davis, P.J., and Davis F.B. (2008). Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: Both actions are integrin- and ERK-mediated. Carcinogenesis  29:62-69
• Lin H.Y., Tang H.Y., Shih A., Keating T., Davis P.J., and Davis F.B. (2007). Thyroxine induces MAPK activation and blocks resveratrol-induced apoptosis in human thyroid cancer cell lines. Steroids 72:180-187.
• Tang H.Y., Shih A., Cao J.H., Davis F.B., Davis P.J., and Lin H.Y. (2006). Inducible COX-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther. 5:2034-2042.
• Lin H.Y., Lansing L, Merillon J-M, Davis F.B., Tang H.-Y., Shih A., Vitrac X, Krisa S., Keating T., Cao H.J., Bergh J.J., Quackenbush S., and Davis, P.J. (2006). Integrin alpha(V)beta3 contains a receptor site for resveratrol. FASEB J. 20:1742-1744.
• Davis F.B., Tang H.Y., Shih A, Keating T., Hercbergs A, Fenstermarker RA, Mousa S, Mousa A, Davis P.J., and Lin H.Y. (2006). Acting via cell surface receptor, thyroid hormone is a growth factor for glioma cells. Cancer Research. 66:7270-7275.
• Parikh R.R., Gildener-Leapman N., Narendran A., Lin H.Y., Lemanski N., Bennett J.A., Jacobson H.I., and Andersen T.T. (2005) Prevention of N-methyl-N-nitrosourea-induced breast cancer by alpha-fetoprotein (AFP)-derived peptide, a peptide derived from the active site of AFP. Clin Cancer Res. 23:8512-8520
• Shih A., Zhang S.L., Cao H.J., Tang H.-Y., Davis F.B., Davis P.J., and Lin H.Y. (2004). Disparate effects of thyroid hormone on actions of EGF and TGF-alpha are mediated by cyclic-AMP-dependent kinase II.  Endocrinol. 145:1798-1717.
• Tang H.Y., Lin H.Y., Zhang S., Davis F.B., and Davis P.J. (2004). Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor. Endocrinology. 145:3265-3272.
• Zhang S.L., Cao J.H., Davis F.B., Tang H.Y., Davis P J., and Lin, H.Y. (2004). Estrogen inhibits resveratrol-induced posttranslational modification of p53 and apoptosis in breast cancer cells. Brit. J. Cancer 91:178-185.
• Shih A., Zhang S.L., Cao J.H., Boswell S., Wu Y-S, Tang H.Y., Lennartz M.R., Davis F.B., Davis P.J., and Lin H.Y. (2004). Inhibitory effect of EGF on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.  Mol. Cancer Ther. 3:1355-1364.