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James J. McSharry, Ph.D.
Senior Scientist
Director, Virology Therapeutics and Pharmacodynamics
Laboratory
Professor, Biomedical Sciences, School of Public
Health, State University of New York
Professor Emeritus, Center for Immunology and Infectious
Disease, Albany Medical College
Virology Therapeutics and Pharmacodynamics Laboratory
Telephone: (518) 641-6462
Fax: (518) 641-6304
jmcsharry@ordwayresearch.org
Research Focus
Dr. McSharry has developed rapid, quantitative
methods involving flow cytometry for measuring virus replication
in virus-infected cells. He has used this technology to develop
drug susceptibility assays for antiviral drugs effective against
human immunodeficiency virus, herpes simplex viruses, cytomegalovirus,
and influenza viruses. He is applying this technology to study the
pharmacodynamics of antiviral drugs effective against human immunodeficiency
virus, hepatitis C virus, and poxviruses.
The focus of the laboratory is to use a novel
in vitro hollow fiber pharmacodynamic system and mathematical
modeling to define the dosage and frequency of administration of
antiviral drugs. Specifically, to design dosing strategies that
optimize their effectiveness and minimize the probability that the
infecting pathogens will become resistant to the antiviral agent
during therapy. The mathematical modeling studies are carried out
by Dr. George Drusano of the Ordway Research Institute.
Selected Publications
www.pubmed.com
McSharry, JJ, R Costantino, E
Robbiano, R Echols, R Stevens, and JM Lehman. 1990. Detection and
quantitation of human immunodeficiency virus-infected peripheral
blood mononuclear cells by flow cytometry. J. Clin. Microbiol.
28:724-733.
McSharry, JJ, A McDonough, B
Olson, C Talarico, M Davis, and KK Biron. 2001, Inhibition of ganciclovir-susceptible
and -resistant human cytomegalovirus clinical isolates by the benizimidazole
L-riboside 1263W94. Clin. Diag. Lab Immunol. 8:1279-1281.
McSharry, JJ, A McDonough, B
Olson, S Hallenberger, J Reefschlaeger, W Bender and GL Drusano.
2001. Susceptibilities of human cytomegalovirus clinical isolates
to BAY-28-4766, BASY43-6965 and ganciclovir. Antimicrob Agents.
Chemother. 45:2925-2927.
Chutkowski, C, B Olson, A McDonough, J Mahoney
and JJ McSharry. 2002. Use of a single monoclonal
antibody to determine the susceptibilities of herpes simplex virus
type 1 and type 2 clinical isolates. Clin. Diag. Lab Immunol.
9:1379-1381.
McSharry, JJ, AC McDonough, BA
Olson, and GL Drusano. 2004. Phenotypic drug susceptibility assay
for influenza virus neuraminidase inhibitors. Clin. Diag. Lab.
Immunol. 11:21-28.
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