Recent Publications

Cancer Center

Eugenia Broude, Ph.D.

Shtutman, M., Maliyekkel, A., Shao, Y., Carmack, C.S., Baig, M., Warholic, N., Cole, K., Broude, E.V., Harkins, T.T., Ding, Y., and Roninson, I.B. (2010). Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing. Proc. Natl. Acad. Sci. USA, 107, 7377-7382.
Demidenko, Z.N., Kalurupalle, S., Hanko, C., Lim, C.U., Broude, E., Blagosklonny, M.V. (2008). Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis. Oncogene. 2008 Jul 24;27(32):4402-10
Broude, E.V., Loncarek, J., Wada, I., Cole, K., Hanko, C., Swift, M. and Roninson, I.B. (2008). Mitotic catastrophe in cancer therapy. In "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown and D.E. Bredesen, Editors, Informa Healthcare, pp. 307-320.
Roninson, I.B. and Broude, E.V. (2008). Treatment-induced tumor cell senescence and its consequences. In "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown and D.E. Bredesen, Editors, Informa Healthcare, pp. 223-249.
Broude, E.V., Loncarek, J., Wada, I., Cole, K., Hanko, C., and Roninson, I.B. (2008). Fluorescent and phase contrast video microscopy of mitotic catastrophe in irradiated tumor cells. DVD supplement to "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown and D.E. Bredesen, Editors, Informa Healthcare.

Michael T. Fasullo, Ph.D.

Fasullo, M., Tsaponina, O., Sun, M., and Chabes, A., Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants. Nucleic Acids Res. 2010 Mar;38(4):1195-203. Epub 2009 Dec 3
Fasullo, M.T., Sun, M., and Egner P. AFB1-DNA adducts stimulate both sister chromatid exchanges and mutation in Saccharomyces cerevisiae through a MEC1 (ATR), RAD53, DUN1-dependent pathway. Mol Carcinog. 47: 608-615, 2008
Fasullo, M. T. and Sun, M. The Saccharomyces cerevisiae checkpoint genes checkpoint genes RAD9, CHK1, and PDS1 are required for hyper-recombination in a Saccharomyces cerevisiae mec1 (ATR) hypomorphic mutant. Cell Cycle 7: 2418 – 2426, 2008
Fasullo, M. T. and Sun, M. UV but not X rays stimulate homologous recombination between sister chromatids and homologs in a Saccharomyces cerevisiae mec1 (ATR) hypomorphic mutant. Mutat. Res., 648: 73-81, 2008

Gennadi V. Glinsky, M.D., Ph.D.

Glinsky GV. Human genome connectivity code links disease-associated SNPs, microRNAs and pyknons. Cell Cycle. 2009 8: 925-930. PMID: 19229130
Glinsky, GV. Quantitative analysis of circulating tumor cells as a survival predictor in metastatic castration-resistant prostate cancer: missing parts in a superb study. Clin Cancer Res. 2009 15: 1504-5. PMID: 19228753
Glinsky, GV. 2008. “Stemness” genomics law governs clinical behavior of human cancer: Implications for decision making in disease management. Journal of Clinical Oncology, 26: 2846-2853.
Glinsky, GV. 2008. Disease phenocode analysis identifies SNP-guided microRNA maps (MirMaps) associated with human "master" disease genes. Cell Cycle, 7: 3680-94. PMID: 19029827 [PubMed - indexed for MEDLINE]
Glinsky, GV. 2008. SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways. Cell Cycle, 7: 3564-76. PMID: 19001869 [PubMed - indexed for MEDLINE]
Glinsky, GV. 2008. An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway. Cell Cycle, 7: 2570-2583. PMID: 18719369
Glinsky, GV. 2008. Phenotype-defining functions of multiple non-coding RNA pathways. Cell Cycle, 7:1630-1639. PMID: 18677102
Glinskii VG, Glinsky GV. Emerging genomic technologies and the concept of personalized medicine. Cell Cycle. 2008 7: 2278-85. PMID: 18677102
Glinsky GV. Regenerative medicine: clinical relevance, implications and limitations of the stem cell-based therapies. Cell Cycle 2008 7: 3292-3. PMID: 18948738 [PubMed - indexed for MEDLINE]
Glinsky GV. Regenerative medicine: evidence for remarkable healing power of adult (somatic) stem cells. Cell Cycle 2008 7: 1697. PMID: 18728405 [PubMed - indexed for MEDLINE]
Glinsky GV. Remarkable features of tiny RNA molecules: highlights of revolutionary discoveries on the path from the bench to bedside. Cell Cycle. 2008 7: 2451. PMID: 18719381 [PubMed - indexed for MEDLINE]

Igor B. Roninson, Ph.D.

Shtutman, M., Maliyekkel, A., Shao, Y., Carmack, C.S., Baig, M., Warholic, N., Cole, K., Broude, E.V., Harkins, T.T., Ding, Y., and Roninson, I.B. (2010). Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing. Proc. Natl. Acad. Sci. USA, 107, 7377-7382
Prencipe, M., Fitzpatrick, P., Gorman, S., Mosetto, M., Klinger, R., Furlong, F., Harrison, M., O'Connor, D., Roninson, I.B., O'Sullivan, J., and McCann, A. (2009). Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro. Br. J Cancer 101, 1900-1908.
Gravina, S., Lescai, F., Hurteau, G., Brock, J.B., Saramaki, A., Salvioli, S., Franceschi, C., and Roninson, I.B. (2009). Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging 1, 470-480 (commentary in Aging 1, 442-443, 2009).
Chan, C.Y., Carmack, C.S., Long, D., Maliyekkel, A., Shao, Y, Roninson, I.B., and Ding, Y. (2009). A structural interpretation of the effects of GC-content on efficiency of RNA interference. BMC Bioinformatics 10, Suppl 1:S33.
Roninson, I.B. and Broude, E.V. (2008). Treatment-induced tumor cell senescence and its consequences. In "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown and D.E. Bredesen, Editors, Informa Healthcare, pp. 223-249.
Broude, E.V., Loncarek, J., Wada, I., Cole, K., Hanko, C., Swift, M. and Roninson, I.B. (2008). Mitotic catastrophe in cancer therapy. In "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown and D.E. Bredesen, Editors, Informa Healthcare, pp.307-320.
Roninson, I.B. and Broude, E.V. (2008). Treatment-induced tumor cell senescence and its consequences. In "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown and D.E. Bredesen, Editors, Informa Healthcare, 223-249.
Broude, E.V., Loncarek, J., Wada, I., Cole, K., Hanko, C., and Roninson, I.B. (2008). Fluorescent and phase contrast video microscopy of mitotic catastrophe in irradiated tumor cells. DVD supplement to "Beyond Apoptosis: How Anticancer Agents Stop the Growth of Tumor Cells", I.B. Roninson, J.M. Brown
and D.E. Bredesen, Editors, Informa Healthcare.

Stewart Sell, M.D.

Ilic Z, Crawford D, Vakaria, D, Egner PA, Sell S. Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1. Toxicol. & Applied Pharmacol. 242:241–246, 2010.
McKinstry KK, Strutt TM, Buck A, Curtis J, Dibble JP, Huston Gail, Tighe M, Hamada H, Sell S, Dutton RW, Swain SL. IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J. Immunol. 182: 7353–7363, 2009.
Guest I, Ilic Z, Ma J, Glinsky G, Sell S. Direct and indirect contribution of bone marrow derived cells to cancer. Int. J. Cancer. Published Online: 8 Oct 2009. PMID: 19816927
Glinskii AB, Ma J, Ma S, Grant D, Lim CU, Sell S, Glinsky GV.
Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders. Cell Cycle 23:3925-3942, 2009.
Sell S, Glinsky G. Targeted therapy of cancer stem cells and transit amplifying cells. in Cancer Stem Cells, (W. Farrar, ED) Oxford U. Press, In press
Sell S. History of Cancer Stem Cells, in Regulatory Networks in Stem Cells. (Rajasekar, VK, Vemuri M., Eds); Humana Press, March, 2009.
Sell S. Stem Cells and Cancer: An Introduction. (Majumder, S. Ed0 Springer Sicence+Business Media, LLC 2009, DOI 10.1007/978-0-387-89611-3_1, 2009.
Sell S, Leffert HL. Liver Cancer Stem Cells. J. Clin. Oncology.26:2800-2805, 2008.
Swenson ES, Guest I, Ilic Z, Mazzeo M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte nuclear factor-1 as a marker of epithelial phenotype reveals marrow–derived hepatocytes, but not duct cells, after liver injury in mice. Stem Cells. 7:1768-1777, 2008: PMID: 18467658
Sell, S. Alpha-fetoprotein, Stem Cells, and Cancer. The Abbot Award Lecture. Tumor Biol. 29:161-180, 2008 (DOI: 10.1159/000143402)

Center for Biodefense and Emerging Infections

James J. McSharry

McSharry, JJ, MR Deziel, K Zager, Q Weng GL Drusano. 2009. Pharmacodynamics of cidofovir for vacccina virus infection in an in vitro hollow-fiber infection model system. Antimicrob. Agents Chemother. 53(1):129-35.
Paskaleva EE, X Lin, K Duus, JJ McSharry, JC Veille, C Thornber, Y Liu, DY Lee, M Canki. 2008. Sargassum fusiforme fraction is a potent and specific inhibitor of HIV-1 fusion and reverse transcriptase. Virol. J. 15 (5): 5-8.
Beauchemin CA, JJ McSharry, GL Drusano, JT Nguyen, GT Went, RM Ribeiro and AS Perelson. 2008. Modeling amantadine treatment of influenza A virus in vitro. J. Theor. Biol. 254 (2): 439-51.

Institute for Clinical Pharmacodynamics

Paul G. Ambrose, Pharm.D. , FIDSA
Sujata M. Bhavnani, Pharm.D., M.S.
Alan Forrest, Pharm.D
Jeffrey Hammel, M.S.
Olanrewaju Okusanya, Pharm.D., M.S., BCPS
Christopher Rubino, Pharm.D., BCPS
Scott Van Wart, M.S.

Ambrose PG, Meagher AK, Passarell JA, Van Wart SA, Circincione BB, Rubino CM, Korth-Bradley JA, Babinchak T, Ellis-Grosse E. Use of clinically derived exposure-response relationships to evaluate potential tigecycline-Enterobacteriaceae susceptibility breakpoints. Diagn Microbiol Infect Dis. 2009; 63:38-42.
Bulitta JB, Ly NS, Yang JC, Forrest A, Jusko WJ, Tsuji BT. Development and qualification of a pharmacodynamic model for the pronounced inoculums effect of ceftazidime against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009; 53:46-56.
Pai MP, Sakoglu U, Peterson SL, Lyons CR, Sood R. Characterization of BBB permeability in preclinical model of cryptococcal meningoencephalitis using magnetic resonance imaging. J Cereb Blood Flow Metab. 2009; 29:545-53.
Ambrose PG, Meagher AK, Passarell JA, Van Wart SA, Circincione BB, Bhavnani SM, Ellis-Grosse E. Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci. Diagn Microbiol Infect Dis. 2009; 63:155-9.
Pai MP, Sample ML Mercier RC, Spilde MN. Activity and ultrastructural effects of antifungal combinations against simulated candida endocardial vegetations. Antimicrob Agents Chemother. 2008; 52:2367-76.
Baddley JW, Patel M, Bhavnani SM, Moser SA, Andes DR. Association of fluconazole pharmacodynamics in mortality in patients with candidemia. Antimicorb Agents Chemother. 2008; 52:3022-8.
Tsuji BT, Yang JC, Forrest A, Kelchlin PA, Smith PF. In vitro pharmacodynamics of novel rifamycin ABI-0043 against Staphylococcus aureus. J Antimicrob Chemother. 2008; 62:156-60.
Drusano GL, Okusanya OO, Okusanya A, Van Scoy B, Brown DL, Kulawy R, Sörgel F, Heine HS, Louie A. Is 60 days of ciprofloxacin administration necessary for postexposure prophylaxis for Bacillus anthracis? Antimicrob Agents Chemother. 2008; 53:3973-9.
Bradley JS, Sauberan JB, Ambrose PG, Bhavnani SM, Rasmussen MR, Capparelli EV. Meropenem pharmacokinetics, pharmacodynamics and Monte Carlo simulation in the neonate. Pediatr Infect Dis J. 2008; 27:794-9.
Pharmacokinetics-pharmacodynamics of quinolones against Streptococcus pneumoniae in patients with community-acquired pneumonia. Diagn Microbiol Infect Dis. 2008; 62:99-101.
Ambrose PG. Use of pharmacokinetics and pharmacodynamics in a failure analysis of community-acquired pneumonia: implications for future clinical trial study design. Clin Infect Dis. 2008; 47 Suppl 3:S225-31.
Jones RN, Biedenbach DJ, Ambrose PG, Wikler MA. Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolones-resistant strains. Diagn Microbiol Infect Dis. 2008; 62:110-2.

Signal Transduction

Faith B. Davis, M.D.
Paul J. Davis, M.D.
Harold K. Kimelberg, Ph.D.
Hung-Yun Lin, Ph.D.
Min Zhou, M.D., Ph.D.

Yalcin M, Dyskin E, Lansing L, Bharali DJ, Mousa SS, Bridoux A, Hercbergs AH, Lin HY, Davis FB, Glinsky GV, Glinskii A, Ma J, Davis PJ, Mousa SA. Tetraiodothyro-acetic acid (tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid. J Clin Endocrinol Metab 95:1972-1980, 2010.
Luidens MK, Mousa SA, Davis FB, Lin HY, Davis PJ. Thyroid hormone and angiogenesis. Vasc Pharmacol 52:142-145, 2010.
Glinskii AB, Glinsky GV, Lin HY, Tang HY, Sun M, Davis FB, Luidens MK, Mousa SA, Hercbergs AH, Davis PJ. Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac). Cell Cycle 8:3562-3570, 2009.
Davis FB, Lin HY, Luidens MK, Zhou M, Mousa SA. Similar and shared nongenomic mechanisms of action of estrogen and thyroid hormone. Immun, Endoc & Metab Agents in Med Chem 9:84-89, 2009.
Lin HY, Sun M, Tang HY, Lin C, Luidens MK, Mousa SA, Incerpi S, Drusano GL, Davis FB and Davis PJ. L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Am J Physiol Cell Physiol 296:C980-C991, 2009.
Davis PJ, Zhou M, Davis FB, Lansing L, Mousa SA, Lin HY. Mini-review: Cell surface receptor for thyroid hormone and nongenomic regulation of ion fluxes in excitable cells. Physiology and Behavior, 2009 (epub ahead of print).
Davis PJ, Davis FB and Mousa SA. Thyroid hormone-induced angiogenesis. Current Cardiology Reviews 5:12-16, 2009.
Lin HY, Sun M, Lin C, Tang H-Y, London D, Shih A, Davis FB and Davis PJ. Androgen-induced human breast cancer cell proliferation is mediated by discrete mechanisms in estrogen receptor--positive and –negative breast cancer cells. J Steroid Biochemistry and Molecular Biology 113:182-188, 2009.
Davis P.J., Davis F.B., Lin H.Y., Hercbergs A.H., and Mousa S.A. (2009). Nongenomic Actions of thyroid hormone. HOT THYROIDOLOGY
Lin HY, Sun M, Tang HY, Lin C, Luidens MK, Mousa SA, Incerpi S, Drusano GL, Davis FB and Davis PJ. L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Am J Physiol Cell Physiol 296:C980-C991, 2009.
Zhang H, Xie M, Schools GP, Feustel PF, Wang W, Lei T, Kimelberg HK, Zhou M (2009) Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res. 9;1247:196-211.
Kimelberg, H.K. (2009). Astrocyte heterogeneity or homogeneity? In Astrocytes in (Patho)physiology of the nervous system. Parpura V and Haydon P.G. (eds) pp 1-26. Springer, New York
Mongin A.A. and Kimelberg H.K. (2009). Regulation of cell volume in neural cells. Vol 8 pp.81-87. Encyclopedia of Neuroscience. (L.R. Squire, Editor). Oxford: Academic Press.
Kimelberg H.K (2009). Functions of mature mammalian astrocytes; a current view. The neuroscientist. In press
Mongin A.A. and Kimelberg H.K. (2009). Regulation of cell volume in neural cells. Vol 8 pp.81-87. Encyclopedia of Neuroscience. (L.R. Squire, Editor). Oxford: Academic Press.
Kimelberg H.K. (2009). Functions of mature mammalian astrocytes; a current view. The neuroscientist. In press
Lin H.Y., Sun M.Z., Tang H.Y., Wu Y.-H., Grandis J.R., Davis P.J., and Davis F.B. (2008). Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. J. Cell. Biochem. 104:2131-2142.
Mousa S.A., Bergh J.J., Dier E., Rebbaa A., O’Connor L.J., Yalcin M., Aljada A., Dyskin E., Lin H.Y., Davis F.B., and Davis P.J. (2008). Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor. Angiogenesis 11:183-190.
Davis P.J., Davis F.B. and Lin H.Y. (2008). Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors. Steroids 73:1013-1007
Zhang H, Schools GP, Lei T, Wang W, Kimelberg HK, Zhou M (2008) Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. 212(1):44-52.
Xie M, Wang W, Kimelberg HK, Zhou M (2008) Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices. J Cereb Blood Flow Metab. 28(3):456